Effect of Eriobotrya japonica on blood glucose levels of normal and alloxan diabetic rabbits.
نویسندگان
چکیده
The alcoholic extract of the leaves of Eriobotrya japonica was administered in doses of 100, 150 and 200 mg/kg body weight to normal and alloxan diabetic rabbits. The blood glucose levels were estimated before and 1,2,3 and 4 hours after the administration of the extract. The extract exerted a significant (P < 0.05) hypoglycaemic effect in normal rabbits which was however short-lived. The hypoglycaemic effect was not significant ( P> 0.1) in alloxan-treated rabbits. The doses used did not show acute toxicity and behavioural changes. From this study, it may be concluded that the extract acts by initiating the release of insulin from pancreative beta cells of normal rabbits (JPMA 38:108, 1988).
منابع مشابه
Hypoglycemic Activity of Ruellia tuberosa Linn (Acanthaceae) in Normal and Alloxan-Induced Diabetic Rabbits
The present study was carried out to determine the hypoglycemic activity of the methanolic extract and solvent fractions (n-hexane and ethyl acetate) of Ruellia tuberosa in normal and alloxan-induced diabetic rabbits. Optimum dose of R. tuberosa for hypoglycemic activity was determined by oral administration of the methanolic extract (ME) to normal and diabetic ...
متن کاملHypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice.
The hypoglycemic effects of Eriobotrya japonica seeds were investigated in type 2 diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats and KK-A(y) mice. The rats and mice were fed on a diet containing 10% powdered Eriobotrya japonica seeds with the coat intact for 4 months. Although the blood glucose concentration in the OLETF rats fed on the control diet without Eriobotrya japonica seeds wa...
متن کاملEfficacy of Abroma augusta on Biochemical and Histomorphological Features of Alloxan-Induced Diabetic Rabbits
Background and Objectives: Medicinal plants are well documented for possessing antidiabetic or antihyperglycaemic potential. Abroma augusta seems to have the same effect in treating diabetes mellitus. The aim of the present experiment was to report the efficacy of the aqueous extract of the leaves of A. augusta on biochemical and histological abnormaliti...
متن کاملEffects of Acacia arabica and Caralluma edulis on blood glucose levels of normal and alloxan diabetic rabbits.
The powdered seeds of Acacia arabica and roots of Caralluma edulis were administered in doses of 2, 3 and 4 gm/kg body-weight to normal and alloxan-diabetic rabbits. The blood glucose levels were estimated before and 2, 4, 6 and 8 hours after the administration of plant suspension. The powdered seeds of Acacia arabica exerted a significant (P less than 0.05) hypoglycemic effect in normal rabbit...
متن کاملHypoglycaemic effects of methanolic extract of Canscora decussata (Schult) whole-plant in normal and alloxan-induced diabetic rabbits.
In present study hypoglycaemic effects of the crude powdered C. decussata and its methanolic extract (ME) in alloxan diabetic rabbits were evaluated. The hypoglycaemic effect was measured by blood glucose, insulin level, HbA1c and his to pathology of pancreas. Glucose lowering effect of the ME was studied in diabetic rabbits. The effects of extract on blood glucose, body weight, food in take, f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- JPMA. The Journal of the Pakistan Medical Association
دوره 38 4 شماره
صفحات -
تاریخ انتشار 1988